Restoring Sinus Rhythm Reverses Cardiac Remodeling and Reduces Valvular Regurgitation in Patients With Atrial Fibrillation - Centre de recherche Saint-Antoine - UMR S938 Accéder directement au contenu
Article Dans Une Revue Journal of the American College of Cardiology Année : 2022

Restoring Sinus Rhythm Reverses Cardiac Remodeling and Reduces Valvular Regurgitation in Patients With Atrial Fibrillation

Laurie Soulat-Dufour
  • Fonction : Auteur
Sylvie Lang
  • Fonction : Auteur
Karima Addetia
  • Fonction : Auteur
Stephane Ederhy
  • Fonction : Auteur
Saroumadi Adavane-Scheuble
  • Fonction : Auteur
Marion Chauvet-Droit
  • Fonction : Auteur
Marie-Liesse Jean
  • Fonction : Auteur
Pascal Nhan
  • Fonction : Auteur
Rim Ben Said
  • Fonction : Auteur
Iris Kamami
  • Fonction : Auteur
Pauline Issaurat
  • Fonction : Auteur
Elodie Capderou
  • Fonction : Auteur
Camille Arnaud
  • Fonction : Auteur
Roberto Lang
  • Fonction : Auteur
Ariel Cohen
  • Fonction : Auteur

Résumé

Introduction: Patients with established coronary artery disease (CAD) are at very high risk for cardiovascular events. Methods: The DAUSSET study is a national, multicenter, non-interventional study that included very high-risk CAD patients followed by French cardiologists. It aimed to describe real-life clinical practices for low-density lipoprotein (LDL) cholesterol control in the secondary prevention of CAD. Results: A total of 912 patients (mean age, 65.4 years; men, 76.1%; myocardial infarction, 69.4%; first episode, 80.1%) were analyzed. The LDL cholesterol goal was 70 mg/dL in most cases (84.9%). The LDL cholesterol goal <70 mg/dL was achieved in 41.7% of patients. Of the 894 (98.0%) patients who received lipid-lowering therapy, 81.2% had been treated more intensively after the cardiac event, 27.0% had been treated less intensively and 13.1% had been maintained. Participating cardiologists were very satisfied or satisfied with treatment response in 72.6% of patients. Moderate satisfaction or dissatisfaction with lipid-lowering therapy was related to not achieving objectives (100%), treatment inefficacy (53.7%), treatment intolerance (23.4%) and poor adherence (12.3%). Conclusion: These real-world results show that lipid control in very high-risk patients remains insufficient. More than half of the patients did not achieve the LDL cholesterol goal. Prevention of cardiovascular events in these very high-risk patients could be further improved by better education and more intensive lipid-lowering therapy.
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hal-04012866 , version 1 (22-07-2024)

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Laurie Soulat-Dufour, Sylvie Lang, Karima Addetia, Stephane Ederhy, Saroumadi Adavane-Scheuble, et al.. Restoring Sinus Rhythm Reverses Cardiac Remodeling and Reduces Valvular Regurgitation in Patients With Atrial Fibrillation. Journal of the American College of Cardiology, 2022, 79 (10), pp.951-961. ⟨10.1016/j.jacc.2021.12.029⟩. ⟨hal-04012866⟩
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